Mats Troedsson

Mats Troedsson

Mats Troedsson

Mats Troedsson

Professor

Faculty Gluck
Gluck Equine Research Center 1400 Nicholasville Rd. Lexington, KY 40546

Last Revised: Apr 23rd, 2024

Professional Biography

Reproductive Health

Dr. Troedsson’s research encompasses reproductive immunology, infertility and pregnancy loss in horses, and has contributed to advancements in the pathophysiology, diagnosis and treatment of equine endometritis, in particular breeding-induced endometritis and the role of seminal plasma proteins in the innate immune response to breeding. He has also contributed with pioneer research on early diagnostics and treatment of equine placentitis as well as other areas of reproductive health in mares and stallions. His former graduate students have obtained faculty positions and serve as academic leaders at US and International Universities. Dr. Troedsson is board certified in the American College of Theriogenology and the European College of Animal Reproduction, and has served in numerous leadership positions. Current and recent research include

  • Bacterial biofilm associated proteins as potential diagnostics for endometritis
  • Identification of biomarkers for high-risk pregnancies
  • The effect of seminal plasma on immune tolerance during pregnancy, and metabolism of the offspring
  • Degradation of endometrial cups by immune-modulatory treatment
  • Pathophysiology of endometrial fibrosis 

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Scholars@UK

Publications:

Selected peer-reviewed publications during the last three years

177. Esteller-Vico, A., Ball, B.A., Walter, J., Hughes, S., Squires, E.L., Troedsson, M.H.T. (2021) Changes in circulating concentrations of testosterone and estrone sulfate after human chorionic gonadotropin stimulation and subsequent to castration in two-year-old stallions. Anim. Reprod. Sci. https://doi.org/10.1016/j.anireprosci.2020.106670.

178.* Fedorka, C.E., El-Sheikh Ali, H., Walker, O.F., Scoggin, K.E., Dini, P., Loux, S.C., Troedsson, M.H.T., Ball, B.A. (2021) The imbalance of the Th17/Treg axis involved in equine ascending placental infection. J. Reprod. Immunology. https://doi.org/10.1016/j.jri.2020.103268

179.* Fedorka, C.E., Ball, B.A., Walker, O.F., McCormack, M.E., Scoggin, K.E., Kennedy, L., Squires, E.L., Troedsson, M.H.T. (2021) Alterations of Circulating Markers During Late Term Pregnancy Complications in the Horse. Part I: Cytokines. J. Eq. Vet. Sci. https://doi.org/10.1016/j.jevs.2021.103425

180.* Fedorka, C.E., Ball, B.A., Wynn, M.A.A., McCormack, M.E., Scoggin, K.E., Esteller-Vico, A., Curry, T.,

Kennedy, L., Squires, E.L., Troedsson, M.H.T. (2021) Alterations of Circulating Markers During Late Term Pregnancy Complications in the Horse. Part II: Steroid Hormones and AFP. J. Eq. Vet. Sci. doi:10.1016/j.jevs.2021.103395

181. Shingo, H., Dini, P., Esteller-Vico, A., Scoggin, K.E., Squires, E.L., Troedsson, M.H.T., Daels, P., Nambo, Y., Ball, B.A. (2021) Estrogen-regulated angiogenesis in the equine placenta. Int. J. Mol. Sc. doi.org/103390/ijms222212116

182. de la Fuente, A., Scoggin, C., Bradecamp, E., Ali, H., Troedsson, M.H.T., Meyers, S., Dini, P. (2021) Transcriptome characterization of equine oocyte maturation. Reprod. Fert. Develop. doi.org/10.1071/RDv34n2Ab146

183.* Fedorka, C.F., Troedsson, M.H.T. (2021) The use of immunomodulators in equine reproduction. Clin. Theriogenology 13:238-246.

184.* Fedorka, C.E., El-Sheikh Ali, H., Scoggin, K.E., Loux, S.C., Ball, B.A., Troedsson, M.H.T. (2022) TNF signaling during equine placental infection leads to pro-apoptotic and necroptotic outcomes. Am. J. Repr. Immun. https://doi.org/10.1016/j.jri.2022.103655.

185. Williams, N.J., Slovis, N.M., Browne, N.S., Troedsson, M.H.T., Giguėre, S., Hernandez, J.A. (2022) Enterococcus durans infection and diarrhea in Thoroughbred foals. J. Vet. Int. Med. 36(6):2224-2229; doi.org/10.1111/jvim.16568

186. Alghamdi, A.S., Fedorka, C.E., Scoggin, K.E., Vico, A.E., Beatty, K., Davolli, G., Ball, B.A., Troedsson, M.H.T. (2023) Binding of equine seminal lactoferrin/ superoxide dismutase (SOD-3) complex is biased towards dead spermatozoa. Animals 13(1), 52; https://doi.org/10.3390/ani13010052.

187. Fedorka, C.E., El-Sheikh Ali, H., Ball, B.A., Troedsson, M.H.T. (2023) Galectinology of equine pregnancy. Animals 13(1), 129; https://doi.org/10.3390/ani13010129

188. Fedorka, C.E., El-Sheikh Ali, H., Ball, B.A., Troedsson, M.H.T. (2023) Galectinology of equine placental disease. Vet. Sci. 10(3), 218; https://doi.org/10.3390/vetsci10030218

189. Fedorka, C.E., Troedsson, M.H.T. (2023) The Immune Response to Ascending Placentitis: A Narrative Review. Theriogenology, 203:11-20. https://doi.org/10.1016/j.theriogenology.2023.03.002

190.* Miller, L.M.J., Woodward, E.M. Campos, J.R., Williams, N., Squires, E.L., Troedsson, M.H.T. (2023) Expression of Sperm Protein at 22kDa (SP22) on spermatozoa and in the stallion’s reproductive tract prior to and following heat-induced testicular regulation. Andrology https://doi.org/10.1111/andr.13464

191. de la Fuente, A., Scoggin, C., Bradecamp, E., Martin-Pelaez, S., van Heule, M., Troedsson, M.H.T., Daels, P., Meyers, S., Dini, P. (2023) Dynamics of in vitro equine oocyte maturation in horses: a transcriptomic approach. Int. J. Mol. Sci. https//doi.org/10.3390/ijms241813718.

192. Fedorka, C.E., Schnobrich, M.R., Muderspach, N.D., Scoggin, K.E., Dedman, M.T., Weigle, K.E., May, M.G., Twist, H., Linse, C.R., Douglas, R.H., Troedsson, M.H.T. (2024) Utilizing an immunostimulant (Settle®) to hasten the degradation of endometrial cups. Eq. Vet. J. http://doi.org/10.1111/evj.14079

193.* Doty, A.L., Miller, L.M.J., Fedorka, C.F., Troedsson, M.H.T. (2024) The role of equine CRISP-3 in the interaction between ploymorphonuclear neutrophils (PMNs) and populations of viable or dead spermatozoa, and bacteria. Theriogenology. 219(15):22-31 https://doi.org/10.1016/j.theriogenology.2024.02.014.

194.* Muderspach, N.D., Troedsson, M.H.T., Ferreira-Dias, G., Agerholm, J.S., Christoffersen, M. (2024) Distribution of degenerative changes in the equine endometrium as observed in a single versus two biopsies. Theriogenology. 213:52-58 https://doi.org/10.1016/j.theriogenology.2023.09.0018.

195. Bailey, C.S., Leite, T., Troedsson, M.H.T. Observations from the trenches on focal mucoid (nocardioform) placentitis. Clin. Theriogenology (under review).

 * graduate student or a resident as first author

 

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Education

Diplomate, European College of Animal Reproduction, 2002
Diplomate, American College of Theriogenologists, 1993
PhD, School of Veterinary Medicine, Reproductive Immunology, Comparative Pathology Graduate Division, Davis, University of California, 1991
DVM, The Royal Veterinary College, Stockholm, Sweden, 1975

Contact Information

Brett Sponseller
Director, Gluck Equine Research Center

108A Gluck Equine Research Center 1400 Nicholasville Rd. Lexington, KY 40546-0215

(859) 257-4757

brett.sponseller@uky.edu