Reproductive Health

Dr. Troedsson’s research encompasses reproductive immunology, infertility and pregnancy loss in horses, and has contributed to advancements in the pathophysiology, diagnosis and treatment of equine endometritis, in particular breeding-induced endometritis and the role of seminal plasma proteins in the innate immune response to breeding. He has also contributed with pioneer research on early diagnostics and treatment of equine placentitis as well as other areas of reproductive health in mares and stallions. His former graduate students have obtained faculty positions and serve as academic leaders at US and International Universities. Dr. Troedsson is board certified in the American College of Theriogenology and the European College of Animal Reproduction, and has served in numerous leadership positions. Current and recent research include

• Bacterial biofilm associated proteins as potential diagnostics for endometritis
• Identification of biomarkers for high-risk pregnancies
• The effect of seminal plasma on immune tolerance during pregnancy, and metabolism of the offspring
• Degradation of endometrial cups by immune-modulatory treatment
• Pathophysiology of endometrial fibrosis 

Follow me on:
Scholars@UK

Publications:

Selected peer-reviewed publications during the last three years

184.*      Fedorka, C.E., El-Sheikh Ali, H., Scoggin, K.E., Loux, S.C., Ball, B.A., Troedsson, M.H.T. (2022) TNF signaling during equine placental infection leads to pro-apoptotic and necroptotic outcomes. Am. J. Repr. Immun. https://doi.org/10.1016/j.jri.2022.103655.

185.        Williams, N.J., Slovis, N.M., Browne, N.S., Troedsson, M.H.T., Giguėre, S., Hernandez, J.A. (2022) Enterococcus durans infection and diarrhea in Thoroughbred foals. J. Vet. Int. Med. 36(6):2224-2229; doi.org/10.1111/jvim.16568 

186.        Alghamdi, A.S., Fedorka, C.E., Scoggin, K.E., Vico, A.E., Beatty, K., Davolli, G., Ball, B.A., Troedsson, M.H.T. (2023) Binding of equine seminal lactoferrin/ superoxide dismutase (SOD-3) complex is biased towards dead spermatozoa. Animals 13(1), 52; https://doi.org/10.3390/ani13010052.

187.        Fedorka, C.E., El-Sheikh Ali, H., Ball, B.A., Troedsson, M.H.T. (2023) Galectinology of equine pregnancy. Animals 13(1), 129; https://doi.org/10.3390/ani13010129

188.        Fedorka, C.E., El-Sheikh Ali, H., Ball, B.A., Troedsson, M.H.T. (2023) Galectinology of equine placental disease. Vet. Sci. 10(3), 218; https://doi.org/10.3390/vetsci10030218

189.        Fedorka, C.E., Troedsson, M.H.T. (2023) The Immune Response to Ascending Placentitis: A Narrative Review. Theriogenology, 203:11-20. https://doi.org/10.1016/j.theriogenology.2023.03.002

190.*      Miller, L.M.J., Woodward, E.M. Campos, J.R., Williams, N., Squires, E.L., Troedsson, M.H.T. (2023) Expression of Sperm Protein at 22kDa (SP22) on spermatozoa and in the stallion’s reproductive tract prior to and following heat-induced testicular regulation. Andrology https://doi.org/10.1111/andr.13464 

191.        de la Fuente, A., Scoggin, C., Bradecamp, E., Martin-Pelaez, S., van Heule, M., Troedsson, M.H.T., Daels, P., Meyers, S., Dini, P. (2023) Dynamics of in vitro equine oocyte maturation in horses: a transcriptomic approach. Int. J. Mol. Sci. https//doi.org/10.3390/ijms241813718.

192.        Fedorka, C.E., Schnobrich, M.R., Muderspach, N.D., Scoggin, K.E., Dedman, M.T., Weigle, K.E., May, M.G., Twist, H., Linse, C.R., Douglas, R.H., Troedsson, M.H.T. (2024) Utilizing an immunostimulant (Settle®) to hasten the degradation of endometrial cups. Eq. Vet. J. http://doi.org/10.1111/evj.14079

193.*      Doty, A.L., Miller, L.M.J., Fedorka, C.F., Troedsson, M.H.T. (2024) The role of equine CRISP-3 in the interaction between ploymorphonuclear neutrophils (PMNs) and populations of viable or dead spermatozoa, and bacteria. Theriogenology. 219(15):22-31 https://doi.org/10.1016/j.theriogenology.2024.02.014.

194.*      Muderspach, N.D., Troedsson, M.H.T., Ferreira-Dias, G., Agerholm, J.S, Christoffersen, M. (2024) Distribution of degenerative changes in the equine endometrium as observed in a single versus two biopsies. Theriogenology. 213:52-58 https://doi.org/10.1016/j.theriogenology.2023.09.0018.

195.        Bailey, C.S., Leite, T., Troedsson, M.H.T. (2024) Observations from the trenches on focal mucoid (nocardioform) placentitis. Clin. Theriogenology 16: https://doi.org/10.58292/CT.v16.10636.

196.        Troedsson, M.H.T., Doty, A.L., Fedorka, C.F. (2024) The physiology of seminal plasma proteins in the equine female reproductive tract. J. Clin. Exp. Reprod. Med. 1(1):1-7.

197.        Fedorka, C.E., Scoggin, K.E., El-Sheikh Ali, H., Troedsson, M.H.T. (2024) Evaluatiung the IL-6 family of cytokines throughout equine gestation. Am. J. Reprod. Immunol. 92:e13910. https://doi.org/10.1111/aji.13910.

198.        Fedorka, C.E., El-Sheikh Ali, H., Scoggin, K.E., Coleman, S., Humphrey, E.A., Trout, L., Troedsson, M.H.T. The effect of seminal plasma on the equine endometrial transcriptome. Reprod. Dom. Anim. 59:e14711. https://doi.org/10.1111/rda.14711.

199.        Kabir, A., Lamichhane, B., Habib, T., Adams, A., El-Sheikh Ali, H., Slovis, N.M., Troedsson, M.H.T., Helmy, Y.A. (2024) Antimicrobial Resistance in Equines: A Growing Threat to Horse Health and Beyond- A Comprehensive Review. Antibiotics, 13(8):713. https://doi.org/10.13390/antibiotics.13080713

200.        Fedorka, C.E., Scoggin, K.E., Coleman, S., Hatzel, J., Burleson, M., Troedsson, M.H.T. (2025) Unveiling the equine placental transcriptome: a novel study on ICSI-derived pregnancies. Theriogenology 237:120-128. https://doi.org/10.1016/j.theriogenology.2025.02.013

201.*      N.D. Muderspach, P.L. Wood, K.E. Scoggin, C.E. Fedorka, L.M.J. Miller, M.G. May, M.H.T. Troedsson, G. Ferreira-Dias, J.S. Agerholm, M. Christoffersen. A lipidomic profiling of endometrtial tissue and plasma from mares with normal and fibrotic endometrium. Biol. Reprod. (under review).

202.*      N.D. Muderspach, Daucke, R., M. Wennekers Nielsen, K.E. Scoggin, C.E. Fedorka, L.M.J. Miller, M.G. May, M.H.T. Troedsson, G. Ferreira-Dias, J.S. Agerholm, M. Christoffersen. Proteomic profiling of endometrial tissue and plasma from mares with endometrial fibrosis. Biol. Reprod. (under review).

203.        Marchio, S.P., El-Sheikh Ali, H., Scott, M.A., Fernandes, C.B., Scoggin, K.E., Troedsson, M.H.T., Boakari, Y. Amniotic membrane transcriptome analysis idetntifies genes and mechanisms associated with inflammatory response during ascending placentitis. Scientific Reports (under review).

204.        Scoggin, K.E., Adlan, F., Fedorka, C.E., Rakha, S.I., Stout, T.A.E., Troedsson, M.H.T., El-Sheikh Ali, H. Gestation-stage related chages in IGF axis components in the equine placenta. Biomolecules (submitted).

* Graduate student, post-doc, or resident as first author